Hiroaki Shirahase Selected Research

Insulin (Novolin)

5/2018

Therapeutic effects of the allosteric protein tyrosine phosphatase 1B inhibitor KY-226 on experimental diabetes and obesity via enhancements in insulin and leptin signaling in mice.

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Hiroaki Shirahase Research Topics

Disease

4	Osteoporosis 01/2024 - 01/2014
4	Atherosclerosis 08/2010 - 01/2003
3	Obesity 01/2021 - 01/2014
3	Body Weight (Weight, Body) 01/2021 - 01/2014
3	Inflammation (Inflammations) 06/2006 - 09/2004
2	Mucopolysaccharidosis I (Hurler Syndrome) 01/2023 - 01/2023
2	Insulin Resistance 01/2021 - 01/2019
2	Hyperglycemia 01/2019 - 06/2008
1	Bone Diseases (Bone Disease) 01/2024
1	Mucopolysaccharidoses 01/2023
1	Cardiomegaly (Heart Hypertrophy) 01/2021
1	Weight Gain 01/2021
1	Bone Fractures (Bone Fracture) 01/2019
1	Hepatocellular Carcinoma (Hepatoma) 05/2018
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2014
1	Necrosis 01/2008
1	Pleurisy (Pleuritis) 06/2006
1	Edema (Dropsy) 01/2006
1	Arthritis (Polyarthritis) 09/2004

Drug/Important Bio-Agent (IBA)

2	Diphosphonates (Bisphosphonates)IBA 01/2023 - 01/2019
2	EnzymesIBA 01/2023 - 01/2023
2	Parathyroid Hormone (Parathormone)IBA 01/2023 - 01/2019
2	AntibodiesIBA 01/2023 - 01/2019
2	1,2,3,4-tetrahydroisoquinolineIBA 01/2023 - 08/2010
2	Iduronidase (alpha-L-Iduronidase)IBA 01/2023 - 01/2023
2	Nonsense Codon (Nonsense Mutation)IBA 01/2023 - 01/2023
2	Pioglitazone (Actos)FDA Link 01/2021 - 05/2018
2	AdiponectinIBA 01/2021 - 01/2021
2	Glucose (Dextrose)FDA LinkGeneric 01/2019 - 05/2018
2	Triglycerides (Triacylglycerol)IBA 01/2019 - 05/2018
2	N- (4,6- dimethyl- 1- pentylindolin- 7- yl)- 2,2- dimethylpropanamideIBA 01/2008 - 01/2004
2	CholesterolIBA 01/2008 - 01/2004
2	Cyclooxygenase InhibitorsIBA 06/2006 - 01/2006
2	Nitroarginine (NG Nitro L Arginine)IBA 06/2006 - 01/2006
2	NG-Nitroarginine Methyl Ester (L-NAME)IBA 06/2006 - 01/2006
2	Nitric Oxide Synthase (NO Synthase)IBA 06/2006 - 01/2006
2	CarrageenanIBA 06/2006 - 01/2006
2	Indomethacin (Indometacin)FDA LinkGeneric 06/2006 - 01/2006
2	oxidized low density lipoproteinIBA 01/2004 - 01/2003
1	Gentamicins (Gentamicin)FDA LinkGeneric 01/2023
1	GlycosaminoglycansIBA 01/2023
1	Proteins (Proteins, Gene)FDA Link 01/2023
1	Bone Density Conservation AgentsIBA 01/2023
1	LuciferasesIBA 01/2023
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 01/2021
1	LigandsIBA 01/2019
1	Therapeutic UsesIBA 05/2018
1	LeptinIBA 05/2018
1	KY-226IBA 05/2018
1	Insulin ReceptorIBA 05/2018
1	Hemoglobins (Hemoglobin)IBA 05/2018
1	Non-Receptor Type 1 Protein Tyrosine PhosphataseIBA 05/2018
1	Insulin (Novolin)FDA Link 05/2018
1	7- (2- (2- (2- cyclopentylvinyl)- 5- methyloxazol- 4- yl)- ethoxy)- 2- (2,4- hexadienoyl)- 1,2,3,4- tetrahydroisoquinoline- 3- carboxylic acidIBA 01/2014
1	Rosiglitazone (Avandia)FDA Link 01/2014
1	Dihydrotachysterol (AT 10)IBA 01/2014
1	compound 21IBA 08/2010
1	pactimibeIBA 08/2010
1	PPAR gammaIBA 06/2008
1	acetyl-LDLIBA 01/2008
1	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 01/2006
1	Collagen Type II (Type II Collagen)IBA 09/2004
1	Dinoprostone (PGE2)FDA Link 09/2004
1	ProstaglandinsIBA 09/2004
1	NitratesIBA 09/2004
1	NitritesIBA 09/2004
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 09/2004
1	LipidsIBA 01/2004
1	LDL Lipoproteins (beta Lipoproteins)IBA 01/2003
1	Drug CarriersIBA 01/2003
1	Sterol O-AcyltransferaseIBA 01/2003
1	Lipoproteins (Lipoprotein)IBA 01/2003

Therapy/Procedure

2	Therapeutics 01/2024 - 06/2006
1	Activities of Daily Living (ADL) 01/2019
1	Oral Administration 05/2018